Putting the fire out with light

Chili peppers contain an activator of heat-sensitive pain receptors. An LMU team has now converted an antagonist to the compound into a light-sensitive regulator of such receptors that can differentially modulate the effects ...

Researchers block morphine's itchy side effect

Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor pain often ...

Chili peppers help to unravel the mechanism of pain

Capsaicin, the active ingredient in chili peppers, is most often experienced as an irritant, but it may also be used to reduce pain. A new work published by Drs. Feng Qin and Jing Yao in this week's PLoS Biology uses capsaicin ...

From cone snail venom to pain relief

Conotoxins are bioactive peptides found in the venom that marine cone snails produce for prey capture and defense. They are used as pharmacological tools to study pain signalling and have the potential to become a new class ...

Painkillers relieve zebrafish larvae discomfort

Lynne Sneddon is a myth buster. Having debunked the fisherman's legend that fish don't feel pain, Sneddon, from the University of Liverpool, UK, has become a leading figure in the movement to reduce, replace and refine the ...

Intractable pain may find relief in tiny gold rods

A team of scientists at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) has developed a novel technique using tiny gold rods to target pain receptors.

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