Feedback loop maintains basal cell population

Notch – the protein that can help determine cell fate – maintains a stable population of basal cells in the prostate through a positive feedback loop system with another key protein – TGF beta (transforming growth factor ...

We need to talk: How cells communicate to activate notch

During formation of multi-cellular organisms, cells need to talk to each other to make critical decisions as to what kind of cell to become, as well as when and where to become that cell type. The Notch signaling system allows ...

Signaling pathway is 'executive software' of airway stem cells

Researchers at Duke University Medical Center have found out how mouse basal cells that line airways "decide" to become one of two types of cells that assist in airway-clearing duties. The findings could help provide new ...

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