(Phys.org) —Two of the most exciting areas of science and technology, synthetic biology and genetic engineering, have just taken a step towards a brave new future in which large-scale synthetic biological circuits composed ...
Signal transduction and perception regulates biological activities to adapt to changing environments. The Pert-Arnt-Sim domains are commonly available sensors found across diverse receptors in bacteria, eukaryotes, and archaea. ...
The breakthrough came on molecular biologist Christopher Garcia's birthday.
Molecular & Computational biology
Mar 10, 2022
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836
The human cellular kinome contains over 500 kinases, accounting for almost 2% of all our genes. It is currently impossible to gauge the phosphorylation status, or even phosphorylation potential, of the entire proteome of ...
In order for tumors to successfully take hold and spread in the body, they typically must meet several developmental milestones. These include things like suppressing apoptosis, cultivating replication and angiogenesis, weaning ...
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
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186
Unlike ordinary cells, cancer cells devote most of their energy to reproducing themselves. To do this, they must trigger alternative metabolic pathways that produce new cellular building blocks, such as DNA, carbohydrates ...
Biochemistry
Aug 27, 2012
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0
(PhysOrg.com) -- Since the 1920s, scientists have known that cancer cells generate energy differently than normal cells, a phenomenon dubbed the 'Warburg effect' after its discoverer, German biochemist Otto Warburg. However, ...
Biochemistry
Apr 6, 2010
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0
When pathogens attack plants, the plant cells almost immediately react. The plant's cells begin to produce different kinds of small molecules called secondary messengers. These messengers travel throughout the cell membrane ...
Plants & Animals
Feb 26, 2024
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1
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.
Molecular & Computational biology
Sep 14, 2023
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142
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which carry out phosphorolysis, the breaking of a bond using an inorganic phosphate group; or with phosphatases, which remove phosphate groups.
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