Understanding the APJ Receptor Binding Site

(PhysOrg.com) -- Apelin is a recently discovered peptide that binds to the apelin (or APJ) G-protein-coupled receptor. Apelin-13 (NH2-QRPRLSHKGPMPF-COOH), one of several cleavage products of the proprotein form of the apelin ...

Mathematically modeling HIV drug pharmacodynamics

37 million people around the world today live with Human Immunodeficiency Virus (HIV), which is responsible for roughly 1.1 million deaths caused by AIDS-related conditions.

A sweet defense against lethal bacteria

(PhysOrg.com) -- There is now a promising vaccine candidate for combating the pathogen which causes one of the most common and dangerous hospital infections. An international team of scientists from the Max Planck Institute ...

Engineers use 'DNA origami' to identify vaccine design rules

By folding DNA into a virus-like structure, MIT researchers have designed HIV-like particles that provoke a strong immune response from human immune cells grown in a lab dish. Such particles might eventually be used as an ...

New discoveries make it harder for HIV to hide from drugs

The virus that causes AIDS is chameleon-like in its replication. As HIV copies itself in humans, it constantly mutates into forms that can evade even the best cocktail of current therapies. Understanding exactly how HIV cells ...

Sneaking spies into a cell's nucleus

(PhysOrg.com) -- Duke University bioengineers have not only figured out a way to sneak molecular spies through the walls of individual cells, they can now slip them into the command center -- or nucleus -- of those cells, ...

Gorilla origins of the last two AIDS virus lineages confirmed

Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists from the Perelman School of Medicine at the University ...

Getting to the core of HIV replication

Viruses lurk in the gray area between the living and the nonliving, according to scientists. Like living things, they replicate but they don't do it on their own. The HIV-1 virus, like all viruses, needs to hijack a host ...

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