Bioengineers can tailor the genomes of cells to create "cellular therapies" that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch ...
Cell & Microbiology
Aug 14, 2023
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1
Artificial intelligence can predict on- and off-target activity of CRISPR tools that target RNA instead of DNA, according to new research published in Nature Biotechnology.
Biotechnology
Jul 3, 2023
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4643
The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and ...
Molecular & Computational biology
Jun 30, 2023
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50
While the presence of harmful critters in your home may be addressed by a call to the exterminator, harmful parasites in the body can be much harder to expel. A single-celled parasite known as Toxoplasma gondii (hereafter ...
Cell & Microbiology
Jun 6, 2023
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19
The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases ...
Bio & Medicine
May 26, 2023
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245
Bacteria are intimately involved in our daily lives. These microorganisms have been used in human history for food such as cheese, yogurt, and wine. In more recent years, through metabolic engineering, microorganisms been ...
Cell & Microbiology
May 10, 2023
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38
Cancer is a complex systemic disease, with accompanying secondary effects that can result in debilitating effects on the human body. Cancer-associated skeletal muscle weakening or loss, also called "cancer cachexia," is a ...
Bio & Medicine
Apr 24, 2023
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8
Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic ...
Biotechnology
Mar 16, 2023
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14
A review of gene editing techniques suggests that the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/Cas) method could be a possible "savior" for rice crops threatened by climate change and high food ...
Biotechnology
Mar 3, 2023
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8
The Hirohide Saito Laboratory has developed cyclic RNA switches that can control gene expression in a cell type-specific manner using miRNAs and RNA-binding proteins and has successfully constructed an artificial gene circuit ...
Cell & Microbiology
Feb 16, 2023
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2
