Preventing the spread of repression

Scientists at the Friedrich Miescher Institute for Biomedical Research have identified a novel and unexpected regulatory activity of RNA at the edge of inactive chromosomal regions. In their publication in Nature Structural ...

Simple moss plants outperform us by gene number

At the genetic level, mosses are more complex than humans: A group of German, Belgian and Japanese scientists, coordinated by Professor Ralf Reski from the University of Freiburg, Germany, published a new study where they ...

The TALE of new tools to study gene regulation

In nearly every organism's genome, scattered between genes that encode proteins, long regulatory regions stretch across expanses of DNA. Understanding what role these so-called enhancer regions play in controlling the activation ...

Fast track to mouse modeling

What genes are responsible for the development of breast cancer? What are the brain cell mutations that lead to the onset of Alzheimer's? To find new therapies, scientists have to understand how diseases are triggered at ...

Scientists shed light on the 'dark matter' of DNA

In each cell, thousands of regulatory regions control which genes are active at any time. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have developed a method that reliably detects these regions ...

Computers 'taught' to ID regulating gene sequences

Johns Hopkins researchers have succeeded in teaching computers how to identify commonalities in DNA sequences known to regulate gene activity, and to then use those commonalities to predict other regulatory regions throughout ...

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