Researchers discover new cancer target
New research published today in the Biochemical Journal describes the discovery of a new cancer target.
Feb 28, 2013
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Feb 28, 2013
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Researchers use SSRL to decipher structural details of deadly enzyme
(Phys.org)—A small team of researchers has used the brilliant X-rays of the Stanford Synchrotron Radiation Laboratory to pin down the crystalline structure of an enzyme complex that scientists had spent ...
Sep 20, 2012
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The modeling of new enzymes helps develop therapies for cocaine abuse
Mapping of protein inhibitors facilitates development of tailor-made anticancer agents
(PhysOrg.com) -- A team of researchers at Karolinska Institutet in Sweden has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. This map may explain the mechanism ...
Feb 20, 2012
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Researchers discover the processes leading to acute myeloid leukemia
Researchers at UC Santa Barbara have discovered a molecular pathway that may explain how a particularly deadly form of cancer develops. The discovery may lead to new cancer therapies that reprogram cells instead ...
Jan 30, 2012
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New test spots early signs of mucopolysaccharidoses -- inherited metabolic disorders
A team of scientists, led by researchers at the University of California, San Diego School of Medicine and Zacharon Pharmaceuticals, have developed a simple, reliable test for identifying biomarkers for mucopolysaccharidoses ...
Jan 08, 2012
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Research supports newborn screening and early treatment for rare genetic disorder, MPS I
In a study that supports the need for newborn screening and early treatment for a rare genetic disorder, researchers at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) and ...
Dec 01, 2010
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New lymphoma treatment shows promise in dogs
Researchers have identified a new target for the treatment of lymphoma and are testing a potential new drug in pet dogs afflicted with the disease. At low doses, the compound, called S-PAC-1, arrested the ...
Sep 07, 2010
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Researchers can watch drug activity in a molecule (w/ Video)
(PhysOrg.com) -- Weill Cornell's Scott Blanchard has developed technology that can observe drug activity in a solitary molecule while in motion. The development may lead to newer, safer drug therapies.
Feb 17, 2010
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Research reveals lipids' unexpected role in triggering death of brain cells
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital ...
Nov 12, 2009
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Inventive approach may improve enzyme replacement therapy for Fabry disease
A new study uses a creative structure-based remodeling strategy to design a therapeutic protein that exhibits significant advantages over currently available treatments for a rare disease that often leads to cardiac and renal ...
Oct 22, 2009
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Genetic variation of enzyme linked with outcomes for women receiving tamoxifen
Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a study in the October 7 issue of JAMA.
Oct 06, 2009
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Transplanted human stem cells prolong survival in mouse model of rare brain disease
A new study finds substantial improvement in a mouse model of a rare, hereditary neurodegenerative disease after transplantation of normal human neural stem cells. The research findings, published by Cell Press in the September ...
Sep 03, 2009
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Botanicals have no effect on hot flashes or cognition: Study (w/ Podcast)
Two studies conducted by researchers at the University of Illinois at Chicago and Northwestern University have found that commonly used botanicals do not have an effect on hot flashes or on cognitive function in menopausal ...
Aug 07, 2009
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Enzyme therapy slows kidney function decline
For men with Fabry disease, enzyme replacement therapy (ERT) with agalsidase alfa slows deterioration of kidney function, reports a study in the online edition of the Journal of the American Society of Nephrology (JASN). "The results ...
Apr 08, 2009
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