Mount Sinai researchers have discovered how the enzyme DNA polymerase delta works to duplicate the genome that cells hand down from one generation to the next. In a study published in Nature Structural & Molecular Biology, ...
Molecular & Computational biology
Oct 3, 2019
0
397
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.
Molecular & Computational biology
Apr 5, 2019
0
121
The message of life is encoded in our genomic DNA through transcription of messenger RNAs and translation of proteins to perform cellular functions. To ensure accurate transcription—a process that transcribes genomic DNA ...
Materials Science
Apr 3, 2019
0
81
Whether revealing a perpetrator with DNA evidence, diagnosing a pathogen, classifying a paleontological discovery, or determining paternity, the duplication of nucleic acids (amplification) is indispensable. In the journal ...
Biochemistry
Mar 12, 2019
1
115
Researchers in Japan have discovered that the DNA inside human cells moves around less when its genes are active. The study, which will be published March 1 in the Journal of Cell Biology, suggests that RNA polymerase II ...
Cell & Microbiology
Mar 1, 2019
0
15
Complex biological systems can be described as a network of chemical processes that take place in molecules. The scientists of the "ChemLife" research initiative at the University of Konstanz are working together in an equally ...
Cell & Microbiology
Sep 19, 2018
0
25
Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity. In a paper published ...
Biotechnology
Aug 22, 2018
0
57
Life is astoundingly diverse. By taking antibiotics to stop infections or using yeast to brew beer, we are co-opting useful products and processes that evolved naturally. But what happens when the trait we want can't be found ...
Biotechnology
Aug 2, 2018
0
416
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
0
11
Scientists have shed light on DNA 'melting' – a crucial process fundamental to all life.
Cell & Microbiology
Jun 22, 2018
0
75
