Cells can read damaged DNA without missing a beat

Scientists have shown that cells' DNA-reading machinery can skim through certain kinds of damaged DNA without skipping any letters in the genetic "text." The studies, performed in bacteria, suggest a new mechanism that can ...

Microelectronics: Automating cancer detection

Microelectronic engineers in Singapore have developed and tested sensor technology that can detect and measure a chemical signature of bladder cancer. The light-based sensor could eventually be used for the early diagnosis ...

Replication of enzyme-nucleotide chimeras

DNA polymerases are the "Xerox machines" that replicate our DNA. They must work with great precision to keep errors from creeping into our genes. In spite of this precision, they still accept building blocks that have been ...

How RNA polymerase II gets the go-ahead for gene transcription

All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. The set of proteins synthesized by a cell in turn determines ...

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