A protein with a dual role: Both repair and mutation

Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team1 ...

Unveiling the cause of onion center rot

Since 1983, the bacteria Pantoea ananatis has been known to infect several important crops including onions, rice, and corn. It was unclear, however, what molecules were involved. A new study, published in mBio, has identified ...

Scientists use Doppler to peer inside cells

Doppler radar improves lives by peeking inside air masses to predict the weather. A Purdue University team is using similar technology to look inside living cells, introducing a method to detect pathogens and treat infections ...

Calcium bursts kill drug-resistant tumor cells

Multidrug resistance (MDR)—a process in which tumors become resistant to multiple medicines—is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that ...

Engineers model mutations causing drug resistance

Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and "second generation" approaches are needed. ...

Nanoimaging the intracellular space to aid drug development

Chemotherapeutics are key players in the clinical setting to fight most types of cancer, and novel chemicals could facilitate new and unique intracellular interactions that modulate the cell machinery and destroy the tumor ...

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