Whitehead Institute researchers have conducted the first genome-wide screen in Apicomplexa, a phylum of single-celled parasites that cause malaria, babesiosis, cryptosporidiosis, and toxoplasmosis. The screen sheds light ...
Biotechnology
Sep 1, 2016
0
540
Whitehead Institute scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within the cellular organelles known as mitochondria, often referred to as the "powerhouses of ...
Cell & Microbiology
Aug 31, 2016
0
8
By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with ...
Diseases, Conditions, Syndromes
Aug 11, 2016
0
6
Whitehead Institute scientists have created a checklist that defines the "naive" state of cultured human embryonic stem cells (ESCs). Such cells can mature into almost any cell type and more closely resemble the unique molecular ...
Cell & Microbiology
Jul 14, 2016
0
30
Whitehead Institute scientists have determined how to use alpaca-derived, single-domain antibody fragments (also called VHHs or nanobodies) to perturb cellular processes in mammalian cells, including the infection of human ...
Cell & Microbiology
Jun 20, 2016
0
6
Whitehead Institute researchers have revealed the architecture of a protein complex that plays a foundational role in the machine that directs chromosome segregation during cell division.
Cell & Microbiology
Nov 19, 2015
0
20
Whitehead Institute scientists have at last answered the long-standing question of how the growth-regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine—itself ...
Cell & Microbiology
Oct 8, 2015
0
17
By teasing apart the structure of an enzyme vital to the infectious behavior of the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially 'drugable' target that could ...
Biochemistry
Aug 24, 2015
0
38
Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of ...
Biotechnology
Jun 4, 2015
0
17
By modifying the CRISPR-Cas genome editing system, Whitehead Institute researchers are now able to manipulate Candida albicans' genome systematically—an approach that could help identify novel targets for therapies against ...
Cell & Microbiology
Apr 3, 2015
0
817
