UCSF scientists find new facts about HIV

Dec 07, 2005

University of California-San Francisco scientists have discovered how the human immunodeficiency virus can be kept dormant and hidden in immune cells.

The findings suggest new potential therapeutic approaches for viral eradication from infected patients, lead author Dr. Warner Greene, professor of medicine, microbiology and immunology, said.

Current combined antiviral therapies that target essential components of replicating HIV fail to achieve eradication of the virus from infected patients. That, said Greene, is due in part to the presence of rare cells harboring silent copies of the HIV virus -- a dangerous reservoir of literally "invisible" viruses that might potentially reactivate and seed a new infection.

Greene and colleagues report significant progress toward the understanding of the molecular mechanisms responsible for maintenance of HIV latency.

Specifically, the team demonstrated viral gene expression is actively repressed by the inhibitory NF-kappaB p50 protein. That inhibition is mediated by an enzyme called HDAC1, which is capable of shutting down gene expression in its vicinity.

The study is explained online in The EMBO Journal.

Copyright 2005 by United Press International

Explore further: Super Bowl athletes are scientists at work

add to favorites email to friend print save as pdf

Related Stories

Using viruses to find the cellular Achilles heel

Jan 22, 2015

Back-to-back studies from researchers at the Gladstone Institutes have exposed new battle tactics employed by two deadly viruses: hepatitis C (HCV) and the Kaposi's sarcoma-associated herpesvirus (KSHV). Published in the ...

Mutation breaks HIV's resistance to drugs

Sep 13, 2012

The human immunodeficiency virus (HIV) can contain dozens of different mutations, called polymorphisms. In a recent study an international team of researchers, including MU scientists, found that one of those mutations, called ...

Some monkeys born with gene that protects against AIDS

May 04, 2011

A certain gene in some monkeys can help boost vaccine protection against simian immunodeficiency virus (SIV), a trait that could help researchers develop better AIDS vaccines for humans, suggested a study ...

Recommended for you

Super Bowl athletes are scientists at work

22 hours ago

Seattle Seahawks cornerback Richard Sherman gets called a lot of things. He calls himself the greatest cornerback in the NFL (and Seattle fans tend to agree). Sportswriters and some other players call him ...

Reintegrating extremist into society

22 hours ago

The UK government's increasingly punitive response to those involved in terrorism risks undermining efforts to successfully reintegrate former extremists, according to research by the University of St Andrews.

Strategies to enhance intelligence analysis

Jan 30, 2015

If you've ever watched a thriller about undercover agents, you probably have the impression that intelligence officers are models of objectivity, pragmatism and sharp, unbiased thinking. However, in reality ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.