UCSF scientists find new facts about HIV

Dec 07, 2005

University of California-San Francisco scientists have discovered how the human immunodeficiency virus can be kept dormant and hidden in immune cells.

The findings suggest new potential therapeutic approaches for viral eradication from infected patients, lead author Dr. Warner Greene, professor of medicine, microbiology and immunology, said.

Current combined antiviral therapies that target essential components of replicating HIV fail to achieve eradication of the virus from infected patients. That, said Greene, is due in part to the presence of rare cells harboring silent copies of the HIV virus -- a dangerous reservoir of literally "invisible" viruses that might potentially reactivate and seed a new infection.

Greene and colleagues report significant progress toward the understanding of the molecular mechanisms responsible for maintenance of HIV latency.

Specifically, the team demonstrated viral gene expression is actively repressed by the inhibitory NF-kappaB p50 protein. That inhibition is mediated by an enzyme called HDAC1, which is capable of shutting down gene expression in its vicinity.

The study is explained online in The EMBO Journal.

Copyright 2005 by United Press International

Explore further: Human ancestors could hold the key to early diagnosis of bone disease

Related Stories

Giant virus revealed in 3-D using X-ray laser

Mar 03, 2015

For the first time, researchers have produced a 3-D image revealing part of the inner structure of an intact, infectious virus, using a unique X-ray laser at the Department of Energy's SLAC National Accelerator ...

Vaccines from a reactor

Mar 02, 2015

In the event of an impending global flu pandemic, vaccine production could quickly reach its limits, as flu vaccines are still largely produced in embryonated chicken eggs. Udo Reichl, Director at the Max ...

Jumping genes have essential biological functions

Feb 19, 2015

"Alu" sequences are small repetitive elements representing about 10% of our genome. Because of their ability to move around the genome, these "jumping genes" are considered as real motors of evolution. However, they were ...

Using viruses to find the cellular Achilles heel

Jan 22, 2015

Back-to-back studies from researchers at the Gladstone Institutes have exposed new battle tactics employed by two deadly viruses: hepatitis C (HCV) and the Kaposi's sarcoma-associated herpesvirus (KSHV). Published in the ...

Recommended for you

Why be creative on social media?

1 hour ago

There are five motivators for creating novel content online, whether blog posts, shared news stories, images, photos, songs, videos or any of the other digital artifacts users of social media and social networking sites share ...

Inoculating against science denial

2 hours ago

Science denial has real, societal consequences. Denial of the link between HIV and AIDS led to more than 330,000 premature deaths in South Africa. Denial of the link between smoking and cancer has caused ...

Report details benefits of investment in basic research

3 hours ago

Last year was a notable one for scientific achievements: In 2014, European researchers discovered a fundamental new particle that sheds light on the origins of the universe, and the European Space Agency ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.