First evidence that bacteria get 'touchy-feely' about dangerous biofilms

May 19, 2008
First evidence that bacteria get 'touchy-feely' about dangerous biofilms
New insights on the formation of biofilms could play a role in diminishing antibiotic resistant infections while enhancing the safety of implant materials. Courtesy of Rocky Mountain Laboratories, NIAID, NIH

Researchers in Massachusetts report for the first time that bacteria use a sense of touch in deciding where to form biofilms. Those colonies of microbes grow on medical implants and other devices and play a key role in the multi-billion-dollar-per-year problem of antibiotic resistant infections.

The finding could lead to safer implant materials for fighting biofilms, which are linked to thousands of deaths each year, the scientists say. It also can be used to develop materials capable of sustaining cultures of important, beneficial bacteria. Their study is scheduled for the June 9 issue of ACS’ Biomacromolecules.

In the new report, Krystyn J. Van Vliet and colleagues note that past research focused on killing microbes that already have formed biofilms, or impregnating surfaces with antimicrobial compounds. Scientists knew about certain surface conditions that affected biofilm formation, though many results were in conflict, and the effect of mechanical stiffness of those surfaces had not been considered previously.

The researchers studied the effects of different polymer materials on the adhesion of Staphylococcus epidermidis, the most common bacterial source of hospital-based infections, and on E. coli. In laboratory tests, they found that the bacteria adhered preferentially to the stiffer polymers, as compared to other polymers.

Altering the stiffness of the polymers used in implants could lead to “smarter” materials for fighting or sustaining biofilm formation, they conclude.

Source: ACS

Explore further: Diabetes drug found in freshwater is a potential cause of intersex fish

Related Stories

Micro fingers for arranging single cells

37 minutes ago

Functional analysis of a cell, which is the fundamental unit of life, is important for gaining new insights into medical and pharmaceutical fields. For efficiently studying cell functions, it is essential ...

Image: Sentinel-1A satellite images Florida

38 minutes ago

The peninsula sits between the Gulf of Mexico to the west, and the Atlantic Ocean to the east. The large body of water at the top of the image is the freshwater Lake Okeechobee. Covering about 1900 sq km, ...

Recommended for you

York's anti-malarial plant given Chinese approval

Apr 24, 2015

A new hybrid plant used in anti-malarial drug production, developed by scientists at the University of York's Centre for Novel Agricultural Products (CNAP), is now registered as a new variety in China.

The appeal of being anti-GMO

Apr 24, 2015

A team of Belgian philosophers and plant biotechnologists have turned to cognitive science to explain why opposition to genetically modified organisms (GMOs) has become so widespread, despite positive contributions ...

Micro fingers for arranging single cells

Apr 24, 2015

Functional analysis of a cell, which is the fundamental unit of life, is important for gaining new insights into medical and pharmaceutical fields. For efficiently studying cell functions, it is essential ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.