A gene implicated in human language affects song learning in songbirds

Dec 04, 2007

Do special “human” genes provide the biological substrate for uniquely human traits, like language" Genetic aberrations of the human FoxP2 gene impair speech production and comprehension, yet the relative contributions of FoxP2 to brain development and function are unknown. Songbirds are a useful model to address this because, like human youngsters, they learn to vocalize by imitating the sounds of their elders.

Previously, Dr. Constance Sharff and colleagues found that, when young zebra finches learn to sing or when adult canaries change their song seasonally, FoxP2 is up-regulated in Area X, a brain region important for song learning.

Published this week in the open-access journal PLoS Biology, Dr. Sebastian Haesler, Dr. Scharff, and colleagues experimentally reduce FoxP2 levels in Area X before zebra finches started to learn their song. They used a virus-mediated RNA interference for the first time in songbird brains.

The birds, with lowered levels of FoxP2, imitated their tutor’s song imprecisely and sang more variably than controls. FoxP2 thus appears to be critical for proper song development. These results suggest that humans and birds may employ similar molecular substrates for vocal learning, which can now be further analyzed in an experimental animal system.

Citation: Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, et al. (2007) Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglianucleus Area X. PLoS Biol 5(12): e321. doi:10.1371/journal.pbio.0050321 (www.plosbiology.org)

Source: Public Library of Science

Explore further: First detailed microscopy evidence of bacteria at the lower size limit of life

add to favorites email to friend print save as pdf

Related Stories

Fresh nuclear leak detected at Fukushima plant

6 hours ago

Sensors at the Fukushima nuclear plant have detected a fresh leak of highly radioactive water to the sea, the plant's operator announced Sunday, highlighting difficulties in decommissioning the crippled plant.

Spacewalking astronauts route cable in 1st of 3 jobs

6 hours ago

(AP)—Spacewalking astronauts routed more than 300 feet (90 meters) of cable outside the International Space Station on Saturday, tricky and tiring advance work for the arrival of new American-made crew ...

Driverless shuttle will be on the move in UK

8 hours ago

(Phys.org) —"Autonomous public transport" is on the minds of planners who envision self-driving vehicles that would cross over short distances, suited for airport transport, industrial sites, theme parks ...

Superfish points fingers over ad software security flaws

10 hours ago

A little-known Silicon Valley startup was caught in a firestorm of criticism this week for making software that exposed Lenovo laptop users to hackers bent on stealing personal information. But Superfish Inc. ...

Recommended for you

A molecular compass for bird navigation

Feb 27, 2015

Each year, the Arctic Tern travels over 40,000 miles, migrating nearly from pole to pole and back again. Other birds make similar (though shorter) journeys in search of warmer climes. How do these birds manage ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.