Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice

Mar 28, 2006

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published today in the open access journal Respiratory Research reveals that a dose of 100 µg of horse anti-serum effectively protects infected mice.

These results suggest that anti-H5N1 antibodies developed in horses could potentially be used to prevent death from H5N1 influenza, or as early treatment for the disease, in humans.

Jiahai Lu from Sun Yat-Sen University in Guangzhou, China and colleagues from other institutions in China infected dog kidney cells in vitro with a lethal dose of H5N1 and simultaneously exposed the cells to horse antibodies against H5N1. Lu et al.'s results show that horse antibodies to H5N1 protected cells against H5N1 in vitro – the cells simultaneously infected with H5N1 and exposed to horse antibodies did not die.

Lu et al. then injected horse antibodies into 40 mice that had been infected with a lethal dose of H5N1 24 hours earlier. The authors also injected horse serum without H5N1 antibodies into a group of mice that acted as controls.

The authors found that 50µg of antibody protected 70% of the mice against death by H5N1 and 100 µg of antibody protected 100% of the mice. The mice in the control group died nine hours after receiving the normal horse serum.

Link to Respiratory Research: respiratory-research.com

Source: BioMed Central

Explore further: Explainer: How to solve a jewel heist (and why it takes so long)

Related Stories

Q&A: Why are antibiotics used in livestock?

8 hours ago

Wal-Mart, the world's biggest retailer, is the latest company to ask its suppliers to curb the use of antibiotics in farm animals. Here's a rundown of what's driving the decision: ...

Recommended for you

Top UK scientists warn against EU exit

12 hours ago

A group of leading British scientists including Nobel-winning geneticist Paul Nurse warned leaving the European Union could threaten research funding, in a letter published in The Times newspaper on Friday.

How we discovered the three revolutions of American pop

13 hours ago

Dr Matthias Mauch discusses his recent scientific analysis of the "fossil record" of the Billboard charts prompted widespread attention, particularly the findings about the three musical "revolutions" that shaped the musical la ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.