Nature Reviews Drug Discovery is a review journal with an emphasis on drug discovery and development. With an impact factor of 28.712 in 2010 it is the leading journal in pharmacology/pharmacy and biotechnology/applied microbiology areas. The reviews are commissioned to leaders in the their specialties (non-commissioned review submissions are discouraged), but are also peer-reviewed after submission. The reviews are supplemented with glossary explanations for non-specialist readers and illustrated with figures drawn by Nature's in-house art editors. Besides reviews, the journal accepts peer-reviewed analysis articles based on existing datasets (e.g. metaanalysis), progress articles that focus on outstanding issues, and perspective articles—typically opinions or historical pieces.
The potential to isolate and regulate the biodynamics of single cells is significant in drug design and screening. However, pre-existing experimental reports in single-cell drug screening must yet provide multiple-dose gradient ...
A new perspective published in Nature Reviews Drug Discovery examines the potential of biomolecular condensates to transform drug discovery. Condensates are membrane-less organelles that form dynamically throughout the cell ...
Biotechnology
Aug 19, 2022
0
9
Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of ...
Plants & Animals
Feb 9, 2021
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152
In an aging population, the social impact of osteoarthritis (OA) can dramatically increase to become the most common musculoskeletal disease. However, at present, therapies are limited to palliative treatments or surgical ...
Using artificial intelligence in drug design would give pharmaceutical research a boost, says Gisbert Schneider. In the medium term, computers could even carry out experiments autonomously.
Machine learning & AI
Mar 28, 2019
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23
Liver-on-a-chip cell culture devices are attractive biomimetic models in drug discovery, toxicology and tissue engineering research. To maintain specific liver cell functions on a chip in the lab, adequate cell types and ...
Microneedles are designed to infuse medications transdermally (through the skin) and relatively painlessly during clinical applications. In a recent study, Richa Mishra and her colleagues developed a new technique to convert ...
From a drug perspective, G protein-coupled receptors are the most utilised cell receptors in the body. They are uniquely accessible at the cell surface, and a third of all drugs sold in the US target them.
Biochemistry
Oct 31, 2017
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3
Researchers at University of the Pacific have developed a biochemical trick that can significantly extend the lifespan of peptides, smaller cousins of proteins. The finding opens up new possibilities for creating peptides ...
Biochemistry
Nov 2, 2015
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83
Although fruit flies don't develop cancer, cancer and stem cell researchers have been learning a great deal from fruit flies - in particular, mutant flies with overgrown organs that resemble hippopotamuses.
Cell & Microbiology
Jul 2, 2015
0
367
