Research reveals new understanding of X chromosome inactivation

(Phys.org)—In a paper published in the Nov. 21 issue of Cell, a team led by Mauro Calabrese, a postdoctoral fellow at the University of North Carolina in the lab of Terry Magnuson, chair of the department of genetics and ...

X chromosome: How genetics becomes egalitarian

In cell biology, men and women are unequal: men have an X chromosome, while women have two. How can we get around this difference? Geneticists from the University of Geneva (UNIGE), Switzerland, turned to some historic research ...

Understanding X-chromosome silencing in humans

Researchers have discovered new insights into how one of the two X-chromosomes is silenced during the development of female human embryos and also in lab-grown stem cells. X-chromosome silencing is essential for proper development ...

Revealing a missing link

When it comes to genes, it’s definitely possible to have too much of a good thing. Accordingly, mammalian females have a mechanism that randomly inactivates one of the two X sex chromosomes within each somatic cell nucleus, ...

Aurora B answers an XIST-ential question

Early in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is transcribed and initiates ...

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