Sex, genes, the Y chromosome and the future of men

The Y chromosome, that little chain of genes that determines the sex of humans, is not as tough as you might think. In fact, if we look at the Y chromosome over the course of our evolution we've seen it shrink at an alarming ...

Unravelling the secrets of maleness

New research has identified the key to becoming male is an enzyme that "unravels" DNA to trigger male development of the embryo, a discovery that may give greater insight into intersex disorders.

Evolution of diverse sex-determining mechanisms in mammals

Scientists historically have argued that evolution proceeds through gradual development of traits. But how can incremental changes apply to the binary switch between two sexes, male or female? Researchers at Case Western ...

Scientists identify key event for sex determination

Scientists at the Institute of Molecular Biology (IMB) in Mainz have identified a protein essential for initiating the development of male sex organs. Loss of the gene Gadd45g results in complete sex reversal of male mice, ...

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