G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, ...
Cell & Microbiology
Apr 20, 2022
0
65
Lipid rafts, a component of the plasma membranes that surround all cells in the human body, are essential in regulating the membranes' structure, among other functions. But they are hard to study because traditional biochemical ...
Biochemistry
Mar 28, 2022
0
25
In a structural analysis that could help inform efforts to develop new drugs for treating a myriad of diseases, RIKEN biologists have shed light on how the interaction between key signaling proteins and their regulatory partners ...
Cell & Microbiology
Mar 15, 2022
0
37
When exposed to stress, bacteria allow their metabolism to take a break during which they suppress, for example, the incorporation of proteins into membranes. Scientists from Marburg, Freiburg and Munich have discovered this ...
Cell & Microbiology
Mar 7, 2022
0
73
How organs develop and how they grow to the right size and shape are fundamental questions in developmental biology. The morphogen Dpp is a signaling molecule controlling the development of different organs with regard to ...
Cell & Microbiology
Nov 11, 2021
0
85
A structural analysis by an all-RIKEN team offers detailed insights into how the function of dedicator of cytokinesis (DOCK) proteins is modulated, and how known disease-related mutations derail that activity.
Cell & Microbiology
Nov 1, 2021
0
29
Supercomputer simulations by RIKEN researchers have revealed how drug binding to a protein target changes as the surrounding environment becomes more cluttered with other proteins. These simulations could help improve drug ...
Biotechnology
Oct 21, 2021
0
73
New research from North Carolina State University demonstrates that genes are capable of identifying and responding to coded information in light signals, as well as filtering out some signals entirely. The study shows how ...
Molecular & Computational biology
Aug 31, 2021
0
1361
Errors in the metabolic processes of mitochondria are responsible for a variety of diseases such as Parkinson's and Alzheimer's. Scientists needed to find out just how the necessary building blocks are imported into the complex ...
Cell & Microbiology
Jul 19, 2021
0
120
A research team from the University of Massachusetts Amherst has created an electronic microsystem that can intelligently respond to information inputs without any external energy input, much like a self-autonomous living ...
Nanomaterials
Jun 8, 2021
2
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