Researchers have discovered a new "hidden" gene in SARS-CoV-2—the virus that causes COVID-19—that may have contributed to its unique biology and pandemic potential. In a virus that only has about 15 genes in total, knowing ...
Cell & Microbiology
Nov 10, 2020
0
1048
Scripps Research chemist Matthew Disney, Ph.D., and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from ...
Cell & Microbiology
Sep 30, 2020
0
209
Infectious viruses come in many shapes and sizes and use slightly different attack mechanisms to make humans and animals sick. But all viruses share something in common: They can only do damage by replicating inside the cells ...
Cell & Microbiology
Sep 22, 2020
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150
Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the corona virus manipulates human cells to ensure its own replication. This knowledge will help to develop drugs and vaccines against ...
Cell & Microbiology
Sep 14, 2020
0
112
An international team of researchers were able visualize how orthoreovirus assembles inside infected cells, using cryo-electron tomography at the Electron Bio-Imaging Center (eBIC) at Diamond Light Source, the UK's national ...
Cell & Microbiology
Sep 9, 2020
0
175
The novel coronavirus uses structures within its RNA to infect cells. Scientists have now identified these configurations, generating the most comprehensive atlas to date of SARS-CoV-2's genome.
Biotechnology
Sep 1, 2020
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37
Many viruses, including HIV and influenza A, mutate so quickly that identifying effective vaccines or treatments is like trying to hit a moving target. A better understanding of viral propagation and evolution in single cells ...
Biochemistry
Aug 20, 2020
0
175
To fight viruses, cells can deploy defense enzymes that progressively destroy viral genome strands starting from one of the two strand ends. However, this degradation mechanism is not effective against epidemic viruses such ...
Molecular & Computational biology
Jul 30, 2020
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5
For the first time, scientists at the Morgridge Institute for Research have generated near atomic resolution images of a major viral protein complex responsible for replicating the RNA genome of a member of the positive-strand ...
Molecular & Computational biology
Jul 20, 2020
2
241
Researchers from the Monash Biomedicine Discovery Institute (BDI) have revealed the structure of a protein complex that is essential for the poliovirus to replicate. The structure may be similar to those in other RNA viruses ...
Cell & Microbiology
Jun 19, 2020
0
2
