Polypharmacology—the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical ...
Biochemistry
Jun 2, 2021
0
6
In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic ...
Molecular & Computational biology
Jun 1, 2021
0
12
Almost all bacteria rely on the same emergency valves—protein channels that pop open under pressure, releasing a deluge of cell contents. It is a last-ditch effort, a failsafe that prevents bacteria from exploding and dying ...
Molecular & Computational biology
Apr 13, 2021
0
280
Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein's interactions with SARS-CoV-2 genetic material.
Biochemistry
Apr 5, 2021
0
235
Most drugs operate via the membranes that surround the body's cells. A study by researchers at Karolinska Institutet in Sweden has now mapped the structure and mechanism of MGST2, a membrane enzyme that, amongst other things, ...
Molecular & Computational biology
Mar 19, 2021
0
16
Researchers have detailed a mechanism in the distinctive corona of COVID-19 that could help scientists to rapidly find new treatments for the virus, and quickly test whether existing treatments are likely to work with mutated ...
Molecular & Computational biology
Feb 19, 2021
0
63
There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called 'checkpoint proteins.' These ...
Bio & Medicine
Feb 2, 2021
0
153
As the scientific community continues researching the novel coronavirus, experts are developing new drugs and repurposing existing ones in hopes of identifying promising candidates for treating symptoms of COVID-19.
Biochemistry
Feb 2, 2021
0
90
Since the beginning of the pandemic, scientists worldwide have been working intensely to precisely characterize the novel SARS-CoV2 virus. Only by understanding in detail how the virus is constructed and how it replicates ...
Cell & Microbiology
Feb 1, 2021
0
540
Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. For example, blocking the signaling protein FAK, a so-called kinase, causes breast cancer ...
Biochemistry
Jan 28, 2021
0
16
