An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light. The investigators at Kobe University ...
Molecular & Computational biology
Dec 8, 2020
0
8
Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism.
Molecular & Computational biology
Nov 11, 2020
0
214
Despite enormous efforts to advance traditional pharmacology approaches, more than three quarters of all human proteins remain beyond the reach of therapeutic development. Targeted protein degradation (TPD) is a novel approach ...
Biochemistry
Aug 3, 2020
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45
When scientists find a potentially dangerous protein on a cell, they might imagine shrinking themselves down to become tiny surgeons, cutting out just the problematic molecule and leaving the healthy parts of the cell intact. ...
Biochemistry
Jul 30, 2020
0
128
Why some biopharmaceuticals have a longer shelf life than others is a problem that has baffled scientists and manufacturers alike. Even the same medication, produced by different manufacturers, can vary in its storage life.
Biochemistry
Sep 28, 2018
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10
The amount of proteins inside cells fluctuates over time, and this affects various functions of the cells. Cells are constantly synthesizing and degrading proteins, and studies have shown that this "see-saw" effect actually ...
Cell & Microbiology
Aug 23, 2018
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4
The research groups led by Dr. Jörg Mansfeld of the Biotechnology Center of the TU Dresden (BIOTEC) and Dr. Caren Norden of the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) have developed a novel ...
Biotechnology
Aug 17, 2018
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7
Iron is essential for cells to function, but excess iron can damage cells. Accordingly, cells have sophisticated molecular mechanisms to constantly sense and adjust iron levels. Disorders of cellular iron metabolism affect, ...
Biochemistry
Sep 20, 2017
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4
Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as "the molecular kiss of death". Tim Clausen's group at the Research ...
Cell & Microbiology
Oct 7, 2016
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6
A team led by MDC researcher Annika Weber has pinpointed the efficient mechanism used by cells to label faulty proteins. The findings, which provide important insights into the functioning of protein quality control in the ...
Cell & Microbiology
Aug 25, 2016
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4
