Nanoparticles help disrupt tumor blood supply, destroy tumors

(Phys.org) —In recent years, cancer researchers have been developing agents that destroy the blood vessels surrounding tumors with the goal of starving tumors to death. Some of these agents, such as tumor necrosis factor-alpha ...

Gold nanoparticles: A new delivery for cancer drugs

(Phys.org) —The protein tumor necrosis factor-alpha (TNF-alpha) is a powerful weapon in the arsenal to control cancer. Unfortunately, as is the case with many potent cancer therapies, the use of TNF-alpha as an anti-cancer ...

Lying and sitting more comfortably

(PhysOrg.com) -- Anyone confined to a wheelchair or a bed has to deal with numerous complications. Frequently, they suffer from bedsores or decubitus ulcers as physicians call them. Bony prominences, such as the sacrum, coccyx ...

Raising fluid walls around living cells

Cell culture plates that are in everyday use in biology can be effectively transformed into microfluidic devices, opening paths for biologists to miniaturize cell-based workflows. In a recent report, Ph.D. researcher Cristian ...

Nanostimulators boost stem cells for muscle repair

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells.

Why many cells are better than one

Researchers from Johns Hopkins have quantified the number of possible decisions that an individual cell can make after receiving a cue from its environment, and surprisingly, it's only two.

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Necrosis

Necrosis (from the Greek νεκρός, "dead", νέκρωσις, "death, the stage of dying, the act of killing") is the premature death of cells and living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.

Cells that die due to necrosis do not usually send the same chemical signals to the immune system that cells undergoing apoptosis do. This prevents nearby phagocytes from locating and engulfing the dead cells, leading to a build-up of dead tissue and cell debris at or near the site of the cell death. For this reason, it is often necessary to remove necrotic tissue surgically, a process known as debridement.

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