Study finds new moves in protein's evolution

Highlighting an important but unexplored area of evolution, scientists at The Scripps Research Institute (TSRI) have found evidence that, over hundreds of millions of years, an essential protein has evolved chiefly by changing ...

Tweaking Mother Nature's chemistry box

Natural enzymes are very clever molecular machines. They are the catalyst for many of nature's chemical transformations. And the conditions they need to perform their task are rather precisely defined. There is a need to ...

Chemists slide a splitting catalyst over DNA for the first time

Chemists from Nijmegen, The Netherlands, have developed a catalyst that binds to DNA, slides over it and splits the molecule in particular places. The researchers were able to do this by synthetically modifying a natural ...

Mimicking living cells: Synthesizing ribosomes

Synthetic biology researchers at Northwestern University, working with partners at Harvard Medical School, have for the first time synthesized ribosomes—cell structures responsible for generating all proteins and enzymes ...

Protein engineers create new biocatalysts

Protein engineers at the California Institute of Technology (Caltech) have tapped into a hidden talent of one of nature's most versatile catalysts. The enzyme cytochrome P450 is nature's premier oxidation catalyst—a protein ...

A new glow for electron microscopy

The glowing green molecule known as green fluorescent protein (GFP) has revolutionized molecular biology. When GFP is attached to a particular protein inside a cell, scientists can easily identify and locate it using fluorescence ...

Iron-sulfur enzymes as candidates for antibiotic development

The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. ...

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