A comprehensive map of the SARS-CoV-2 genome

In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2. While many of its genes were already known at that point, ...

Move over CRISPR, the retrons are coming

While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations. CRISPR-Cas9 can be programmed to find and cut specific pieces of DNA, but editing the ...

Testing the 'two-hit' model for developmental defects

A mutation that deletes a large segment of human chromosome 16 and is associated with neurodevelopmental disorders doesn't work alone. A new functional assay demonstrates how the deletion could be sensitizing the genome such ...

Defensive symbiosis leads to gene loss in bacterial partners

Antibiotics on the cocoon protect the offspring of beewolves, a group of digger wasps, from detrimental fungi. These protective substances are produced by symbiotic bacteria of the genus Streptomyces, which live in these ...

SARS-CoV-2 variants from mink evade inhibition by antibodies

It has been known for about a year that minks can become infected with SARS-CoV-2. The virus had been transmitted from humans to farmed mink and mutated in infected animals. Mutations were acquired in the spike protein, which ...

Scaling up genome editing in tiny worms

Understanding the effects of specific mutations in gene regulatory regions—the sections of DNA and RNA that turn genes on and off—is important to unraveling how the genome works, as well as normal development and disease. ...

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