Scientists discover secreted protein helps repair and grow muscles

Scientists from Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor subunit B (PDGF-B) is continuously secreted from skeletal muscle cells and helps to repair muscles by encouraging ...

Mini but mighty: Tiny WNT messengers help muscles grow

WNT signaling is crucial for the development of organisms and the maintenance of tissue homeostasis, since the WNT messengers are involved in a variety of cellular functions. In skeletal muscle, for example, they can increase ...

Making therapeutic sense of antisense oligonucleotides

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide ...

Researchers create first inhibitor for enzyme linked to cancers

Recent studies showing acid ceramidase (AC) to be upregulated in melanoma, lung and prostate cancers have made the enzyme a desired target for novel synthetic inhibitor compounds. This week in Angewandte Chemie, a top journal ...

Making cities more accessible for everyone

Ron Buliung's interest in urban design initially started with his travels to Europe and India where he saw how different cities dealt with issues such as space, wealth, poverty, street life, congestion and transport.

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