Toxins force construction of 'roads to nowhere'

Toxins released by a type of bacteria that cause diarrheal disease hijack cell processes and force important proteins to assemble into "roads to nowhere," redirecting the proteins away from other jobs that are key to proper ...

Pacemaker channel discovery could lead to better heart drugs

The mechanism by which fat-related molecules called lipids regulate pacemaker ion channel proteins, which help control the heart rhythm, has been revealed in a study from researchers at Weill Cornell Medicine.

Simulating the shear destruction of red blood cells

Many medical devices for treating heart failure generate nonphysiological shear flow. This can trigger the destruction of red blood cells after implantation of ventricular assist devices (VADs), artificial heart valves, vascular ...

Key regulator of cell growth deciphered

The mTOR protein plays a central role in cell growth, proliferation and survival. Its activity varies according to the availability of nutrients and some growth factors, including hormones. This protein is implicated in several ...

A 'door' into the mitochondrial membrane

Mitochondria—the organelles responsible for energy production in human cells—were once free-living organisms that found their way into early eukaryotic cells over a billion years ago. Since then, they have merged seamlessly ...

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