Programmed cell death: The roles of caspase-1 and gasdermin D in apoptosis and pyroptosis
Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa University and others discovered ...