A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting off infections. However, its chronic activation is also implicated in a variety of common diseases, such as Alzheimer's, ...
Molecular & Computational biology
Dec 8, 2023
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21
Excessive activation of inflammasomes is associated with various diseases, including gout, Alzheimer's disease, atherosclerosis, and type 2 diabetes. Given the pivotal role of macrophages in both inflammasome activation and ...
Bio & Medicine
Jul 24, 2023
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7
In an article published in the journal Nature Communications, researchers at the University of São Paulo (USP) in Brazil show how protozoans of the genus Leishmania that cause leishmaniasis manipulate a protein that plays ...
Cell & Microbiology
May 23, 2023
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33
Researchers in the lab of Harvard Medical School structural biologist Hao Wu have deciphered the step-by-step assembly of a molecular complex that's crucial for fighting off infections but can also give rise to myriad diseases ...
Biochemistry
Nov 29, 2022
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20
Centenary Institute research has revealed new insight into tackling mycobacterial infections which are responsible for chronic diseases that include tuberculosis (TB), leprosy and serious skin ulcerations.
Cell & Microbiology
May 12, 2022
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3
New research in mice has uncovered a previously unknown interaction between molecules derived from dietary fiber and an immune cell protein, which triggers protection against infection with Salmonella bacteria. Hitoshi Tsugawa ...
Cell & Microbiology
Sep 29, 2020
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195
It seems too good to be true: a single drug that could treat humanity's worst afflictions, including atherosclerosis, cancer, Alzheimer's, Parkinson's and arthritis. All of these diseases have one thing in common—they involve ...
Other
Feb 19, 2020
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23
Inflammation is a balanced physiological response—the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and chronic diseases. To ...
Cell & Microbiology
Apr 11, 2019
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706
Researchers at St. Jude Children's Research Hospital have discovered the way signals from infectious bacteria gain entry into the cytoplasm of host cells to activate disease-fighting inflammasomes. Inflammasomes are protein ...
Cell & Microbiology
Sep 29, 2016
0
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