Neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease are characterized by the deposition of protein clumps, so-called protein aggregates, in the brains of patients. Even though disease-relevant ...
Biochemistry
Oct 21, 2022
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127
Huntington's chorea is a hereditary disease that leads to cognitive and motor impairments and death. Scientists at the University of Bremen have worked with international partners to elucidate the mechanism by which the mutated ...
Biochemistry
Aug 15, 2022
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261
With their first ever RNA-based inducible system for switching on genes in the roundworm Caenorhabditis elegans (C. elegans), two researchers from the University of Konstanz have closed a significant gap in genetic switches. ...
Biotechnology
Jan 30, 2019
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79
Mutations on a single gene, the huntingtin gene, are the cause of Huntington's disease. They lead to an incorrect form of the correspondent protein. With the help of cryo-electron microscopy researchers from the Max Planck ...
Biochemistry
Feb 22, 2018
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42
Researchers at the Buck Institute have identified and categorized thousands of protein interactions involving huntingtin, the protein responsible for Huntington's disease (HD). To use an analogy of a human social network, ...
Biochemistry
Feb 27, 2014
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5
(Medical Xpress) -- McMaster researchers have discovered a new drug target that may be effective at preventing the onset of Huntington's disease, working much the same way heart medications slow the progression of heart disease ...
Biochemistry
May 31, 2011
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Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type of the protein ...
General Physics
May 18, 2011
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In a paper published in the early online version of Nature Structural and Molecular Biology, researchers at the University of Pittsburgh School of Medicine deconstruct the first steps in an intricate molecular dance that ...
Cell & Microbiology
Mar 8, 2009
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