New work upends understanding of how blood is formed

The origins of our blood may not be quite what we thought. Using cellular "barcoding" in mice, a groundbreaking study finds that blood cells originate not from one type of mother cell, but two, with potential implications ...

Scientists successfully reprogram blood cells

Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme -preventing or reducing organ and central nervous system damage ...

Study uncovers the secret of long-lived stem cells

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells—they give rise to rapidly dividing progenitor cells, which in turn ...

Blood cell family trees trace how production changes with aging

Blood cells make up the majority of cells in the human body. They perform critical functions and their dysfunction is implicated in many important human diseases, from anemias to blood cancers like leukemia. The many types ...

Researchers discover crucial step in creating blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, providing a valuable new insight in the effort to create patient-derived blood stem cells ...

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