Thinking afresh about how cells respond to stress

Just like people, cells get stressed too. A sudden drop in oxygen, overheating, or toxins can trigger a cascade of molecular changes that lead cells to stop growing, produce stress-protective factors, and form stress granules—proteins ...

Sorting and secreting insulin by expiration date

A study in the Journal of Biological Chemistry describes a new way to determine the age of insulin-storage parcels, known as granules, and sheds light on how their age affects their release into the bloodstream. The findings ...

How do our cells respond to stress?

Cells are often exposed to stressful conditions that can be life threatening, such as high temperatures or toxins. Fortunately, our cells are masters of stress management with a powerful response program: they cease to grow, ...

Network of protein-RNA interaction guides phase separation

St. Jude Children's Research Hospital investigators are studying the details of how phase separation leads to the formation of RNA granules, assemblies of protein and RNA that are not bound by a membrane. Their findings show ...

Molecular networks serve as cellular blueprints

Networks are at the heart of everything from communications systems to pandemics. Now researchers have found that a unique type of network also underlies the structures of critical cellular compartments known as membraneless ...

The mysterious 'Tully Monster' fossil just got more mysterious

Every now and again, scientists discover fossils that are so bizarre they defy classification, their body plans unlike any other living animals or plants. Tullimonstrum (also known as the Tully Monster), a 300m-year-old fossil ...

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