Researchers shed further light onto zinc homeostasis in cells

A research group has unearthed how zinc transporter complexes regulate zinc ion (Zn2+) concentrations in different areas of the Golgi apparatus and revealed that this mechanism finely tunes the chaperone protein ERp44.

Cryo-electron microscopy captures structure of a protein pump

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes ...

How a key immune protein is regulated in the cell

Scientists at EPFL have determined how a protein that is critical in our first line of immune defense is regulated in the cell to prevent autoinflammatory diseases.

When dangerous toxins teach fundamental biology

"What our work shows is how a complex in the center of the cell, the ER-Golgi interaction region, controls plasma membrane cholesterol, which is essential for many cellular functions, if not essential for multicellular life," ...

A simpler way to differentiate B cells and T cells

Our immune system is essential for our survival, as our bodies are constantly being exposed to bacteria, viruses, parasites, and other pathogens. Without an immune system, we would quickly lose the war against these pathogens ...

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