Preventing the spread of repression

Scientists at the Friedrich Miescher Institute for Biomedical Research have identified a novel and unexpected regulatory activity of RNA at the edge of inactive chromosomal regions. In their publication in Nature Structural ...

Capsella provides insight into the genomic results of selfing

About 200,000 years ago, Capsella rubella began self fertilizing and split from C. grandiflora. To study the effects of selfing on C. rubella's genome, the Department of Energy Joint Genome Institute sequenced and compared ...

At the heart of the circadian clock

(Phys.org) —Cellular processes in most organisms are regulated by an internal clock, and proteins called cryptochromes are at the core of its central oscillator. The three dimensional structures of cryptochromes from mouse ...

Human Argonaute proteins: To slice or not to slice?

What makes one Argonaute a slicer and another one not? Human Argonaute proteins are key players in the gene regulation process known as RNA interference, RNAi. Professor Joshua-Tor's group of Cold Spring Harbor Laboratory ...

Study tracks the evolutionary history of a cancer-related gene

How and when evolution generates diversity or gives form to proteins, living beings' functional building blocks, are essential questions that still surround the theory of evolution. In humans, the majority of genes have emerged ...

Selectively manipulating protein modifications

Protein activity is strictly regulated. Incorrect or poor protein regulation can lead to uncontrolled growth and thus cancer or chronic inflammation. Members of the Institute of Veterinary Biochemistry and Molecular Biology ...

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