True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Gene crowding affects cell development

The crowding of genes inside the nucleus of a cell affects the way they replicate, and how they are turned on and off, according to a study led by the Liggins Institute at the University of Auckland.

Team identifies structure of tumor-suppressing protein

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide ...

Breakthrough helps explain how DNA is organized in our cells

A team of researchers at the IRCM led by François Robert, PhD, uncovered a critical role for two proteins in chromatin structure. Their breakthrough, recently published in the scientific journal Molecular Cell, helps explain ...

Special chromosomal structures control key genes

Within almost every human cell is a nucleus six microns in diameter—about one 300th of a human hair's width—that is filled with roughly three meters of DNA. As the instructions for all cell processes, the DNA must be ...

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