Rethinking transcription factors and gene expression

Transcription—the reading of a segment of DNA into an RNA template for protein synthesis—is fundamental for nearly all cellular processes, including growth, responding to stimuli, and reproduction. Now, Whitehead Institute ...

The birth of a new protein

A yeast protein that evolved from scratch can fold into a three-dimensional shape—contrary to the general understanding of young proteins—according to new research led by the University of Arizona.

Shaping up against pathogens

Plants can reprogram their genetic material to mount a defensive response against pathogens, which may have applications for agriculture.

Scientists untangle Barr body of inactive X chromosome

Scientists at UMass Medical School, the Institut Curie in Paris and Stanford University, have taken a detailed look inside the small, densely packed structure of the inactive X chromosome found in female mammals called the ...

True love: How transcription factors interact to create a heart

Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo. Without ...

Gene crowding affects cell development

The crowding of genes inside the nucleus of a cell affects the way they replicate, and how they are turned on and off, according to a study led by the Liggins Institute at the University of Auckland.

Team identifies structure of tumor-suppressing protein

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide ...

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