Mechanism of actions of cholecystokinin receptors revealed

Cholecystokinin (CCK) and gastrin are the earliest discovered gastrointestinal hormones. They are the most abundant peptides in gastrointestinal tract and central nervous system, acting as physiologically important hormones ...

Reverse optogenetic tool developed

A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers at Ruhr-Universität Bochum (RUB). They used an opsin—a protein that occurs in the brain and eyes—from zebrafish ...

Individual receptors caught in the act of coupling

A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children's Research Hospital captures movies of receptors on the surface of living cells in unprecedented ...

Molecular simulations show how drugs block key receptors

Many pharmaceuticals work by targeting what are known as 'G-protein-coupled receptors.' In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used ...

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