Understanding key enzyme's role in embryonic development

The catalytic activity of an enzyme called Set1A—a protein that is essential to the viability of embryonic stem cells (ESCs)—is not required for ESC self-renewal, according to a Northwestern Medicine study published in ...

Engineering the P450 enzyme to perform new reactions

Enzymes, the micro machines in our cells, can evolve to perform new tasks when confronted with novel situations. But what if you want an enzyme to do an entirely different job—one that it would never have to do in a cell? ...

Study finds new moves in protein's evolution

Highlighting an important but unexplored area of evolution, scientists at The Scripps Research Institute (TSRI) have found evidence that, over hundreds of millions of years, an essential protein has evolved chiefly by changing ...

Chemists slide a splitting catalyst over DNA for the first time

Chemists from Nijmegen, The Netherlands, have developed a catalyst that binds to DNA, slides over it and splits the molecule in particular places. The researchers were able to do this by synthetically modifying a natural ...

It takes a(n academic) village to determine an enzyme's function

Scientists have sequenced the genomes of nearly 6,900 organisms, but they know the functions of only about half of the protein-coding genes thus far discovered. Now a multidisciplinary effort involving 15 scientists from ...

Selection drives functional evolution of large enzyme families

Researchers at Umeå University, together with researchers at the Institute of Botany, Chinese Academy of Sciences, show in a new study how natural selection drives functional evolution of a large protein family in conifer ...

Discovery of the missing link in evolution of bioluminescence

With bioluminescence—the process that makes fireflies glow—now a mainstay in medical research, scientists are reporting discovery of a "missing link" of its evolution, which represents one of the deepest mysteries about ...

Boosting crop yields in Australia

Andrew Hansen grows wheat, barley, canola, and oats on his farm at Coomandook in South Australia, where his family has farmed the land for more than 60 years. But now the family's way of life is threatened.

DNA catalysts do the work of protein enzymes

(Phys.org) —Illinois chemists have used DNA to do a protein's job, creating opportunities for DNA to find work in more areas of biology, chemistry and medicine than ever before.

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