Discovery of a cellular uptake pathway for larger drug molecules

Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...

Chemists achieve 'molecular editing' feat

Chemists from Scripps Research and the University of California, Los Angeles, have developed methods for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes, which are commonly ...

Researchers cook up new recipe for pretzel-shaped peptides

Researchers from The Australian National University (ANU) have developed a new way to synthesize bicyclic peptides, with major implications for future research into drug treatments for a range of diseases including cancer, ...

AI model directly compares properties of potential new drugs

Biomedical engineers at Duke University have developed an AI platform that autonomously compares molecules and learns from their variations to anticipate property differences critical to discovering new pharmaceuticals. The ...

A new nanoparticle to act at the heart of cells

How can a drug be delivered exactly where it is needed, while limiting the risk of side effects? The use of nanoparticles to encapsulate a drug to protect it and the body until it reaches its point of action is being increasingly ...

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