What's a knot—and what's not—in genomic mapping

While DNA sequencing provides precise, nucleotide-by-nucleotide genomic information, genome mapping provides a bigger-picture perspective of sequenced DNA that can provide valuable structural information. Like mapping roads ...

Biomedical research reveals secrets of cell behavior

(Phys.org) —Knowing virtually everything about how the body's cells make transitions from one state to another – for instance, precisely how particular cells develop into multi-cellular organisms – would be a major ...

How to make chromosomes from DNA

Researchers at the University of Tokyo have discovered a long-overlooked process important for converting a long, string-like DNA molecule into a chromosome. This finding gives us a better understanding of the mechanism of ...

Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...

The protein that assesses distances

A protein of the ISWI family (Imitation Switch, or nucleosome remodelling motors) is endowed with a special property: despite having no organ of sense it is nonetheless able to assess the length of DNA strands. A study just ...

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