DNA damage and faulty repair jointly cause mutations

Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute analysed over 2700 genomes from C. elegans worms in order to better understand the causes of mutations. ...

Gene switch ENO identified as a tomato fruit regulator

A team of researchers from Spain, Germany and France has identified the gene switch ENO (excessive number of floral organs) as a tomato fruit regulator. In their paper published in Proceedings of the National Academy of Sciences, ...

Study finds 'silent' genetic variations can alter protein folding

Proteins, the workhorse of the human cell, help digest our food, carry oxygen through the body, fight off invading microbes, and so much more—but they only function when folded properly into specific, three dimensional ...

Building better base editors

CRISPR-based gene editing has potential therapeutic benefits but also some technical shortcomings. One set of these gene editing tools, base editors, can rewrite the four individual DNA letters, or bases— A, C, T or G—which ...

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