Base editors, which enable production of highly efficient targeted point mutations in genomic DNA without causing double-stranded DNA breaks, hold great promise for gene therapy in human disease and trait improvement in crop ...
Biotechnology
Jul 27, 2020
0
5
Biomolecular engineers at Rice University have found a C-worthy technique that dramatically enhances the accuracy of gene editing.
Molecular & Computational biology
Jul 15, 2020
0
108
Whilst most organisms try to stop their DNA from mutating, scientists from the UK and China have discovered that a common fungus found on bread actively mutates its own DNA as a way of fighting virus-like infections.
Biotechnology
Jun 22, 2020
0
112
Research groups from Instituto Gulbenkian de Ciência (IGC) that study evolution, immunity and microbiology unveiled two new mechanisms in the microbiota: in older populations, the bacterium E. coli evolves in a way that ...
Evolution
Mar 12, 2020
0
18
The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.
Biotechnology
Jan 29, 2020
0
23
New insight into how genetic information stored in human mitochondria is passed from one generation to the next could have important implications for genetic counseling of women planning pregnancies, according to a study ...
Biotechnology
Nov 18, 2019
0
300
Laryngeal paralysis is a serious and sometimes deadly disease in some dog breeds that prevents proper opening of the larynx for breathing. In a new study published 24th October in PLOS Genetics, a team of German specialists ...
Veterinary medicine
Oct 24, 2019
0
6
Non-Mendelian, oligogenic inheritance could be an unrecognized and important element for occurrence of hereditary retinal degenerations (HRDs, comprising retinitis pigmentosa) which are caused by ultra-rare mutations and ...
Evolution
Jul 19, 2019
0
70
Nonsense mutations are single-letter errors in the genetic code that prematurely halt the production of critical proteins. These unfinished proteins are unable to function normally, and nonsense mutations cause 10-15 percent ...
Molecular & Computational biology
Feb 19, 2019
0
45
The human genome has its own proofreaders and editors, and their handiwork is not as haphazard as once thought.
Biotechnology
Nov 7, 2018
2
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