M6P deficiency leaves B cells out of sorts

A group of white blood cells known as B cells, which play a key role in the human immune response, need a protein-targeting signal called mannose 6-phosphate (M6P) in order to proliferate, differentiate, and present immune ...

'Stealth' nanoparticles could improve cancer vaccines

Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven't worked that well. Now, scientists have developed a new way to deliver ...

Mechanism of dengue virus entry into cells revealed

Dengue fever, an infectious tropical disease caused by a mosquito-borne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash. In some people the disease ...

Synthetic polymer could stop the spread of HIV

A precisely designed macromolecule that mimics the binding of HIV to immune system cells could be used to stop the virus from physically entering the body, according to a new study led by a materials scientist at Queen Mary ...

Researchers publish study on neuronal RNA targeting

SUNY Downstate scientist Ilham Muslimov, MD, PhD, along with senior author Henri Tiedge, PhD, professor of physiology and pharmacology and of neurology, published a study suggesting that cellular dysregulation associated ...

A cell turns into a virus factory

Bunyaviruses are poorly researched, despite their diversity and importance in relation to animal and human diseases. ETH Zurich researchers led by virologist Ari Helenius have now discovered the tricks used by the Uukuniemi ...

RNA on the move

In the fruit fly Drosophila, oskar mRNA, which is involved in defining the animal’s body axes, is produced in the nuclei of nurse cells neighbouring the oocyte, and must be transported to the oocyte and along its entire ...

page 5 from 6