When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis.
Biochemistry
Apr 10, 2009
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For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been an impossible, until now. Thanks to a new microscopy technique, ...
Analytical Chemistry
Feb 26, 2013
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Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself ...
Biochemistry
Jan 28, 2015
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52
Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular "alarm bell" to alert the cell to start the repair process, but until recently little was known about how the cell detects and ...
Cell & Microbiology
Aug 13, 2009
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About 95% of all crystal structures obtained for various proteins and deposited in public databases are captured using cryogenic technology. This technology requires frozen conditions. Scientists at St. Jude Children's Research ...
Biochemistry
Aug 19, 2021
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419
A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a ...
Cell & Microbiology
Mar 2, 2015
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14
In a recent study, researchers at Johns Hopkins Medicine suggest that the cell's messenger RNA (mRNA)—the major translator and regulator of genetic material—along with a critical protein called ZAK—spurs the cell's ...
Cell & Microbiology
Jul 2, 2024
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68
Researchers in Freiburg identify a protein responsible for the correct arrangement of the chromosome centromeres in the nucleus.
Cell & Microbiology
Apr 4, 2013
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0
Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
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During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication ...
Biotechnology
May 4, 2015
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