An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light. The investigators at Kobe University ...
Molecular & Computational biology
Dec 8, 2020
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8
A research team from Cologne has discovered that a change in the DNA structure—more precisely in the chromatin—plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl ...
Cell & Microbiology
Oct 13, 2020
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283
DNA damage can occur anywhere in the genome, but most DNA is wrapped around nucleosomes making it inaccessible to the repair machinery. Researchers from the Gasser group now show that DNA damage induces histone depletion, ...
Molecular & Computational biology
Sep 24, 2020
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31
Genomes are routinely subjected to DNA damage. But most cells have DNA repair systems that enforce genome stability and, ideally, prevent diseases like cancer. The trouble gets serious when these systems break down. When ...
Molecular & Computational biology
Sep 16, 2020
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44
Ultraviolet light endangers the integrity of human genetic information and may cause skin cancer. For the first time, researchers at Karlsruhe Institute of Technology (KIT) have demonstrated that DNA damage may also occur ...
Biochemistry
Sep 14, 2020
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595
A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan. The international team's ...
Biotechnology
Aug 21, 2020
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202
A collaborative project between the Center for Genome Integrity, within the Institute for Basic Science (IBS, South Korea), and the Dundee School of Life Sciences, the EMBL's European Bioinformatics Institute (EMBL-EBI), ...
Cell & Microbiology
Jun 8, 2020
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7
The gene p53 is extremely important in cell biology and, hence, the world of cell replacement therapy. Its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the "tumor suppressor ...
Cell & Microbiology
Jun 1, 2020
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1
Researchers at Karolinska Institutet have developed a new sequencing method that makes it possible to map how DNA is spatially organized in the cell nucleus—revealing which genomic regions are at higher risk of mutation ...
Cell & Microbiology
May 26, 2020
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24
DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body. This is due to internal influences such as free radicals, which are produced during inflammatory processes and cellular ...
Biotechnology
May 1, 2020
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20
