A recipe for protein footprinting

Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins—that is, ...

Mystery of giant proton pump solved

Mitochondria are the powerhouses of our cells, generating energy that supports life. A giant molecular proton pump, called complex I, is crucial: It sets in motion a chain of reactions, creating a proton gradient that powers ...

A method for predicting antiviral drug or vaccine targets

A novel method to predict the most promising targets for antiviral drugs or vaccines is based on the conformational changes viral glycoproteins go through during the process of recognition and binding to the host cell. This ...

Nanopore reveals shape-shifting enzyme linked to catalysis

University of Groningen scientists have observed the characteristics of a single enzyme inside a nanopore. They learned that the enzyme can exist in four different folded states, or conformers, that play an active role in ...

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