The discovery of a huge number of long non-protein coding RNAs, aka lncRNAs, in the mammalian genome was a major surprise of the recent large-scale genomics projects. An international team including a bioinformatician from ...
Biotechnology
May 15, 2020
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252
(PhysOrg.com) -- A group of nanoengineers, biologists and physicists have used innovative approaches to deduce the internal structure of chromatin, a key player in DNA regulation, to reconcile a longstanding controversy in ...
Biochemistry
Jul 31, 2009
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0
Inside the cell nucleus, the DNA molecule is found in a densely packed DNA-protein complex known as chromatin. Here the DNA is wrapped around a core of histone proteins and densely packed to form nucleosomes. The structure ...
Cell & Microbiology
Apr 26, 2024
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85
A group led by scientists from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have developed a new method, RADICL-seq, which allows scientists to better understand how RNA interacts with the genome through ...
Biotechnology
Feb 25, 2020
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71
How, where and when genes are expressed determine individual phenotypes. If gene expression is controlled by many regulatory elements, what, ultimately, controls them? And how does genetic variation affect them? The SysGenetiX ...
Molecular & Computational biology
May 2, 2019
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91
In almost every human cell, 2 meters of DNA has to fit within a nucleus that is just 8 millionths of a meter wide. Like wool around a spool, the extreme space challenge requires DNA to wrap around structural proteins called ...
Evolution
Jun 9, 2022
0
47
What if we could program living cells to do what we would like them to do in the body? Having such control—a major goal of synthetic biology—could allow for the development of cell-based therapies that might one day replace ...
Biotechnology
Mar 14, 2016
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50
Researchers have discovered key mechanisms and structural details of a fundamental biological process—how a cell nucleus and its chromosomal material reorganizes itself after cell division. The new findings in chromosomal ...
Cell & Microbiology
Dec 4, 2019
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140
(Phys.org)—An interdisciplinary effort at the Friedrich Miescher Institute for Biomedical Research (FMI) addressed the question of how mRNA content, which is translated into proteins, is regulated in the cell. Supported ...
Cell & Microbiology
Sep 7, 2012
0
0
Ten years after the human genome was first published, researchers have found new clues into the machinery that influences gene function. The team, led by Bradley Bernstein, an associate professor of pathology at Massachusetts ...
Cell & Microbiology
Dec 23, 2011
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