Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists ...
Biochemistry
Dec 6, 2012
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(Phys.org)—Heidelberg molecular biologists have gained new insights into the function of so-called molecular chaperones in protein synthesis. The team headed by Dr. Günter Kramer and Prof. Dr. Bernd Bukau of the DKFZ-ZMBH ...
Cell & Microbiology
Aug 25, 2012
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Amyloid fibers are protein aggregates associated with numerous neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments.
Biochemistry
Jun 19, 2012
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Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure. Scientists ...
Cell & Microbiology
Mar 8, 2012
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(PhysOrg.com) -- Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another and glide safely ...
Cell & Microbiology
Mar 2, 2012
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A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational changes ...
Cell & Microbiology
Jan 13, 2012
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The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Biotechnology
Sep 7, 2011
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UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads ...
Cell & Microbiology
Jan 18, 2011
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In proper society of yesterday, the chaperone insured that couples maintained proper courting rituals. In biology, a group of proteins called chaperonins makes sure that proteins are folded properly to carry out their assigned ...
Cell & Microbiology
Jan 20, 2010
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(PhysOrg.com) -- The World Climate Conference recently took place. Reports about carbon dioxide levels, rising temperatures and melting glaciers appear daily. Scientists from the Max Planck Institute (MPI) of Biochemistry ...
Biochemistry
Jan 14, 2010
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