Proteins are the molecular building blocks and machinery of cells and involved in practically all biological processes. To fulfil their tasks, they need to be folded into a complicated three-dimensional structure. Scientists ...
Cell & Microbiology
Mar 8, 2012
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(PhysOrg.com) -- Imagine two tango dancers sweeping across the dance floor and suddenly encountering a slick spot. To avoid a slip or even a nasty tumble, the pair must work together to support one another and glide safely ...
Cell & Microbiology
Mar 2, 2012
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Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
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A special group of proteins, the so-called chaperons, helps other proteins to obtain their correct conformation. Until now scientists supposed that hydrolyzing ATP provides the energy for the large conformational changes ...
Cell & Microbiology
Jan 13, 2012
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The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Biotechnology
Sep 7, 2011
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UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads ...
Cell & Microbiology
Jan 18, 2011
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In proper society of yesterday, the chaperone insured that couples maintained proper courting rituals. In biology, a group of proteins called chaperonins makes sure that proteins are folded properly to carry out their assigned ...
Cell & Microbiology
Jan 20, 2010
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(PhysOrg.com) -- The World Climate Conference recently took place. Reports about carbon dioxide levels, rising temperatures and melting glaciers appear daily. Scientists from the Max Planck Institute (MPI) of Biochemistry ...
Biochemistry
Jan 14, 2010
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Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually ...
Cell & Microbiology
Dec 28, 2009
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(PhysOrg.com) -- The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. ...
Analytical Chemistry
Nov 26, 2009
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