'Unassuming' enzyme opens way for new medical treatments

It sounds like a plot for a Cold War thriller—training a gene to infiltrate a cell and reside there, unnoticed, until an external self-destruct signal induces it to destroy its new home.

Landing therapeutic genes safely in the human genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)." These are ...

Synthetic gene circuits that improve stem cell quality

Because iPS cells can be made into just about any cell type in the body, they have great promise for cell therapies. One major problem, however, is that not all reprogramming cells successfully become iPS cells, resulting ...

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