Targeting Nsp1 protein could be a pathway for COVID-19 therapy
A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments.
A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments.
Molecular & Computational biology
Feb 16, 2021
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Researchers from the Hong Kong University of Science and Technology (HKSUST) and the University of Hong Kong (HKU) recently demonstrated that the selectivity determinant of Origin Recognition Complex (ORC) for DNA binding ...
Cell & Microbiology
Jan 27, 2021
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57
A chemical probe molecule—a "first gen" molecule that can be used for drug development—that targets a host cell's protein quality control pathways can dramatically reduce infection by Dengue and Zika viruses. The research ...
Cell & Microbiology
Jan 27, 2021
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35
Many proteins are required to maintain the structure, and to preserve the genetic integrity, of DNA. Sliding clamps are proteins that increase the efficiency of DNA replication. Without these proteins, cells would not be ...
Molecular & Computational biology
Dec 10, 2020
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86
A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs ...
Biotechnology
Dec 4, 2020
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175
A team led by LMU's Veit Hornung has shown that a protein found in skin cells recognizes a specific nucleic acid intermediate that is formed during virus replication. This recognition process subsequently induces a potent ...
Cell & Microbiology
Nov 27, 2020
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As the global coronavirus pandemic continues, scientists are not only trying to find vaccines and drugs to combat it, but also to continuously learn more about the virus itself. "By now we can expect the coronavirus to become ...
Cell & Microbiology
Nov 23, 2020
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196
Organelles within cells are tiny engines encapsulating processes that allow the cells to live.
Biochemistry
Nov 13, 2020
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Researchers from UCPH have discovered how a mysterious function of the so called minichromosome maintenance (MCM) proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. ...
Cell & Microbiology
Oct 22, 2020
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136
Loading of replicative helicases onto DNA is a key event during the initiation of chromosomal DNA replication. It takes place at specific chromosomal regions termed origins and is facilitated by the ORC protein complex. By ...
Molecular & Computational biology
Sep 21, 2020
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74